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Bilezikjian, L.-M., Seifert H, Vale W: (1986) Desensitization to growth hormone-releasing factor (GRF) is associated with downregulation of GRF-binding sites
On top of that, the injectable form carries the same practical drawbacks as other injectable peptides: needles, sterile reconstitution, refrigeration, degradation after mixing, and the ongoing friction of maintaining a regular injection routine for benefits that build gradually over months
Due to a limited genetic resource, Parvoviruses use host cellular factors for efficient viral replication
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